Gilson Connect
Oligonucleotides, or oligos, are at the core of some of the most life-changing molecular biology tools used today. From qPCR to antisense gene therapy, oligos have changed what scientists can achieve through synthetic and molecular biology. While synthesis methods continue to advance, one significant challenge remains: oligo purification. Here, we explore the most common approaches to oligo purification, and explain how the right HPLC system can overcome any current and future challenges and help you achieve more accurate results.
Forsythiaside A, a phenylethanoid glycoside, is one of the major active constituents extracted from the air-dried fruits of Forsythia suspensa and has been reported to possess a wide range of pharmacological properties, including anti-inflammatory and antioxidant activities. This application note discusses a simple, fast, and cost-efficient method to prepare pure compounds using a centrifugal partition chromatography (CPC) system.
Whether you’re purifying at small-scale preclinical research levels or larger manufacturing levels, Gilson’s scalable lineup of high performance liquid chromatography (HPLC) and centrifugal partition chromatography (CPC) systems has you covered. These solutions are dependable, flexible, and precise. Our team of experts is here to help you find the one that is right for you.
Researchers are rushing to identify, target, and analyze peptide functions for drug development. Here is what you should know about peptide purification.
In this technical note, we highlight how our software and products help you add extra dimensions to your fraction collection possibilities allowing you to set conditions according to specific requirements for synthetic compound purification.
Vanillin is the major component of natural vanilla, which is one of the most widely used flavoring materials worldwide. In this app note, an ethanolic crude extract of vanilla is used to show the capacity of the PLC 2050 system to work with different types of chromatographic columns.
This technical note shows how the use of a suitable Gilson liquid handler and TRILUTION® LH Software makes it is possible to automate post-purification analysis sample prep. Automating this process reduces manual handling errors
and provides traceability where previously there was none.
Custom manufactured oligonucleotides require additional purification steps after synthesis to separate the full?length products from contaminants. The GX-271 Oligo Purification System can be used to isolate, analyze, and desalt reagent-grade oligonucleotides in one continuous run. Learn how in this application note.
There are many considerations when moving from manual to automated mAb purification, and this technical note discusses some of the hardware and software considerations for maintaining sample integrity and reducing carryover when using a Gilson automated liquid handling system.
Preparative liquid chromatography experiments can mean working at the crossroads of science and art.
